Staying in the game means to continue to exist. To avoid extinction. As long as humanity survives we are in the game. If we become extinct we are out of the game.
In the game and out of the game describes evolution and extinction in more personal terms. Generally one thinks of evolution and extinction as something that happens over a long period of time. Sometimes it can be quite sudden, especially extinction. We are only here because our ancestors stayed in the game. The did what it takes to survive. The term "in the game" also implies that one has to actively work to say in, and if one doesn't do what it takes to stay in the game then you lose, and you are out.
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